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Article

Somatic mutation analysis in melanoma using targeted next generation sequencing.

Experimental and molecular pathology - 1 Oct 2017

Miraflor Allen P, de Abreu Francine B, Peterson Jason D, Turner Scott A, Amos Christopher I, Tsongalis Gregory J, Yan Shaofeng

Abstract excerpt

Advanced stage malignant melanoma often responds poorly to therapy with low survival rates. New therapeutic approaches are based upon a growing understanding of the underlying molecular abnormalities. We demonstrate the feasibility of a next generation sequencing (NGS) assay, which targets hotspots in 50 cancer genes, to assess genotypes that may influence therapeutic selection and response. DNA was extracted...

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Source

Identifiers

PMID: 28822769
DOI: 10.1016/j.yexmp.2017.08.006

Genes

BRAF
NRAS

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