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Article

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.

Nature communications - 22 Aug 2014

Enroth Stefan, Johansson Asa, Enroth Sofia Bosdotter, Gyllensten Ulf

Abstract excerpt

Ideal biomarkers used for disease diagnosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease. Here we show the impact of genetic, clinical and lifestyle factors on circulating levels of 92 protein biomarkers for cancer and inflammation, using a population-based cohort of 1,005 individuals. For 75% of the biomarkers, the levels are significantly...

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Identifiers

PMID: 25147954
DOI: 10.1038/ncomms5684
PMCID: PMC4143927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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