Article
The genomic landscape of juvenile myelomonocytic leukemia.
Nature genetics - 1 Nov 2015
Stieglitz Elliot, Taylor-Weiner Amaro N, Chang Tiffany Y, Gelston Laura C, Wang Yong-Dong, Mazor Tali, Esquivel Emilio, Yu Ariel, Seepo Sara, Olsen Scott, Rosenberg Mara, Archambeault Sophie L, Abusin Ghada, Beckman Kyle, Brown Patrick A, Briones Michael, Carcamo Benjamin, Cooper Todd, Dahl Gary V, Emanuel Peter D, Fluchel Mark N, Goyal Rakesh K, Hayashi Robert J, Hitzler Johann, Hugge Christopher, Liu Y Lucy, Messinger Yoav H, Mahoney Donald H, Monteleone Philip, Nemecek Eneida R, Roehrs Philip A, Schore Reuven J, Stine Kimo C, Takemoto Clifford M, Toretsky Jeffrey A, Costello Joseph F, Olshen Adam B, Stewart Chip, Li Yongjin, Ma Jing, Gerbing Robert B, Alonzo Todd A, Getz Gad, Gruber Tanja, Golub Todd, Stegmaier Kimberly, Loh Mignon L
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies. In addition, few molecular...
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