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Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome

16 Mar 2011

Abstract excerpt

Aberrant DNA methylation contributes to the malignant phenotype in virtually all types of cancer, including myeloid leukemia. We hypothesized that CpG island hypermethylation also occurs in juvenile myelomonocytic leukemia (JMML) and investigated whether it is associated with clinical, hematologic, or prognostic features. Based on quantitative measurements of DNA methylation in 127 JMML cases using mass...

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PMID: 21406719
DOI: 10.1182/blood-2010-08-298968

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