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Article

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Nature communications - 19 Dec 2017

Stieglitz Elliot, Mazor Tali, Olshen Adam B, Geng Huimin, Gelston Laura C, Akutagawa Jon, Lipka Daniel B, Plass Christoph, Flotho Christian, Chehab Farid F, Braun Benjamin S, Costello Joseph F, Loh Mignon L

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in JMML vary markedly from spontaneous resolution to rapid relapse after hematopoietic stem cell transplantation. Here, we hypothesized that DNA methylation patterns would help predict disease outcome and therefore performed genome-wide DNA methylation profiling in a cohort of 39...

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Identifiers

PMID: 29259179
DOI: 10.1038/s41467-017-02178-9
PMCID: PMC5736624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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