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Article

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2016

Lamothe Betty, Wierda William G, Keating Michael J, Gandhi Varsha

Abstract excerpt

PURPOSE: Carfilzomib, while active in B-cell neoplasms, displayed heterogeneous response in chronic lymphocytic leukemia (CLL) samples from patients and showed interpatient variability to carfilzomib-induced cell death. To understand this variability and predict patients who would respond to carfilzomib, we investigated the mechanism by which carfilzomib induces CLL cell death. EXPERIMENTAL DESIGN: Using CLL...

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Identifiers

PMID: 27026200
DOI: 10.1158/1078-0432.CCR-15-2522
PMCID: PMC5118040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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