Article
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer
2021-10-21
Abstract excerpt
Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance. The pro-apoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma (PDAC) subtype. To identify drugs that unleash the death-inducing potential of NOXA, we performed an unbiased drug screening experiment. In NOXA -deficient isogenic cellular models we identified an inhibitor of the transcription factor heter...
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Identifiers and source
- Literature Corpus work
- 319112e6-6333-5701-a97e-d59aa8befc56
- DOI
- 10.1101/2021.10.21.465266