Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic Pathway

14 Sept 2005

Abstract excerpt

The inappropriate expression/activation of cell-cycle-related molecules is associated with neuron death in many experimental paradigms and human neuropathologic conditions. However, the means whereby this links to the core apoptotic machinery in neurons have been unclear. Here, we show that the pro-apoptotic Bcl-2 homology 3 domain-only molecule Bcl-2 interacting mediator of cell death (Bim) is a target of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16162916
DOI: 10.1523/jneurosci.1570-05.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwayPMID 16162916Read ↗

Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways.Semantic proximity Read ↗

FOXO transcription factors directly activate <i>bim</i> gene expression and promote apoptosis in sympathetic neuronsSemantic proximity Read ↗

The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivationSemantic proximity Read ↗

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosisSemantic proximity Read ↗

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomibSemantic proximity Read ↗

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.Semantic proximity Read ↗

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.Semantic proximity Read ↗

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family1Semantic proximity Read ↗

Bim Nuclear Translocation and Inactivation by Viral Interferon Regulatory FactorSemantic proximity Read ↗

Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.Semantic proximity Read ↗

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.Semantic proximity Read ↗

A dominant interfering Myb mutant causes apoptosis in T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.