Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial disease in flies.

Biochimica et biophysica acta - 6 Dec 2004

Jacobs Howard T, Fernández-Ayala Daniel J M, Manjiry Shweta, Kemppainen Esko, Toivonen Janne M, O'Dell Kevin M C

Abstract excerpt

The Drosophila mutant technical knockout (tko), affecting the mitochondrial protein synthetic apparatus, exhibits respiratory chain deficiency and a phenotype resembling various features of mitochondrial disease in humans (paralytic seizures, deafness, developmental retardation). We are using this mutant to analyse the cellular and genomic targets of mitochondrial dysfunction, and to identify ways in which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Drosophila
Share to Mitochondrial Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Transcription, Genetic

Source

Identifiers

PMID: 15576051
DOI: 10.1016/j.bbabio.2004.07.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial disease in flies.PMID 15576051Read ↗

Fly Models of Human Diseases: Drosophila as a Model for Understanding Human Mitochondrial Mutations and Disease.Semantic proximity Read ↗

Modeling mitochondrial encephalomyopathy in Drosophila.Semantic proximity Read ↗

A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafishSemantic proximity Read ↗

A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using ZebrafishSemantic proximity Read ↗

Technical knockout, a Drosophila model of mitochondrial deafness.Semantic proximity Read ↗

A Drosophila model of mitochondrial disease phenotypic heterogeneity.Semantic proximity Read ↗

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.Semantic proximity Read ↗

A <i>Drosophila</i> model of mitochondrial disease phenotypic heterogeneitySemantic proximity Read ↗

Disease models of Leigh syndrome: From yeast to organoids.Semantic proximity Read ↗

Developmental mitochondrial Complex I activity determines lifespanSemantic proximity Read ↗

Mitochondrial diseases in man and mouse.Semantic proximity Read ↗

Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.