Article
Technical knockout, a Drosophila model of mitochondrial deafness.
Genetics - 1 Sept 2001
Toivonen J M, O'Dell K M, Petit N, Irvine S C, Knight G K, Lehtonen M, Longmuir M, Luoto K, Touraille S, Wang Z, Alziari S, Shah Z H, Jacobs H T
Abstract excerpt
Mutations in mtDNA-encoded components of the mitochondrial translational apparatus are associated with diverse pathological states in humans, notably sensorineural deafness. To develop animal models of such disorders, we have manipulated the nuclear gene for mitochondrial ribosomal protein S12 in Drosophila (technical knockout, tko). The prototypic mutant tko(25t) exhibits developmental delay, bang sensitivity,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.