Article
Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy.
PloS one - 1 Jan 2014
Kallianpur Asha R, Jia Peilin, Ellis Ronald J, Zhao Zhongming, Bloss Cinnamon, Wen Wanqing, Marra Christina M, Hulgan Todd, Simpson David M, Morgello Susan, McArthur Justin C, Clifford David B, Collier Ann C, Gelman Benjamin B, McCutchan J Allen, Franklin Donald, Samuels David C, Rosario Debralee, Holzinger Emily, Murdock Deborah G, Letendre Scott, Grant Igor
Abstract excerpt
HIV sensory neuropathy and distal neuropathic pain (DNP) are common, disabling complications associated with combination antiretroviral therapy (cART). We previously associated iron-regulatory genetic polymorphisms with a reduced risk of HIV sensory neuropathy during more neurotoxic types of cART. We here evaluated the impact of polymorphisms in 19 iron-regulatory genes on DNP in 560 HIV-infected subjects from a...
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