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Article

Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy.

AIDS (London, England) - 13 Jul 2006

Kallianpur Asha R, Hulgan Todd, Canter Jeffrey A, Ritchie Marylyn D, Haines Jonathan L, Robbins Gregory K, Shafer Robert W, Clifford David B, Haas David W

Abstract excerpt

OBJECTIVE: Peripheral neuropathy (PN) often complicates nucleoside reverse transcriptase inhibitor (NRTI) therapy of HIV infection and may involve mitochondrial dysfunction. Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN. DESIGN: Case-control...

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Source

Identifiers

PMID: 16847405
DOI: 10.1097/01.aids.0000237366.56864.3c

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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