Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy.

PloS one - 1 Jan 2020

Kallianpur Asha R, Wen Wanqing, Erwin Angelika L, Clifford David B, Hulgan Todd, Robbins Gregory K

Abstract excerpt

OBJECTIVE: People with HIV (PWH) continue to experience sensory neuropathy and neuropathic pain in the combination antiretroviral therapy (cART) era for unclear reasons. This study evaluated the role of iron in a previously reported association of iron-loading hemochromatosis (HFE) gene variants with reduced risk of neuropathy in PWH who received more neurotoxic cART, since an iron-related mechanism also might be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Retroviral Agents
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferritins

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Neuralgia

Share to Peripheral Nervous System Diseases

Share to Receptors, Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 33057367
DOI: 10.1371/journal.pone.0239758
PMCID: PMC7561201

Genes

HFE
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy.PMID 33057367Read ↗

Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy.Semantic proximity Read ↗

Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy.Semantic proximity Read ↗

Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy.Semantic proximity Read ↗

Pharmacogenetics of Nucleoside Reverse-Transcriptase Inhibitor-Associated Peripheral NeuropathySemantic proximity Read ↗

Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.Semantic proximity Read ↗

HIV-associated sensory neuropathy: risk factors and genetics.Semantic proximity Read ↗

Host genetic factors predisposing to HIV-associated neurocognitive disorder.Semantic proximity Read ↗

Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study.Semantic proximity Read ↗

Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.Semantic proximity Read ↗

The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.Semantic proximity Read ↗

Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER.Semantic proximity Read ↗

Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced NeurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.