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Article

Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Shah Gul N, Rubbelke Timothy S, Hendin Joshua, Nguyen Hien, Waheed Abdul, Shoemaker James D, Sly William S

Abstract excerpt

Prior studies with carbonic anhydrase (CA) inhibitors implicated mitochondrial CA in ureagenesis and gluconeogenesis. Subsequent studies identified two mitochondrial CAs. To distinguish the contribution of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called Car5A and Car5B. The Car5A mutation had several deleterious consequences. Car5A null mice were smaller than wild-type...

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Identifiers

PMID: 23589845
DOI: 10.1073/pnas.1305805110
PMCID: PMC3645511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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