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Article

TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2010

Krishnamoorthy Aparna, Clement Matthew E, O'Leary Eileen, Bonventre Joseph V, Vaidya Vishal S

Abstract excerpt

T-cell Immunoglobulin and Mucin domain 2 (TIM2) belongs to the receptor family of cell surface molecules expressed on kidney, liver, and T cells. Previous studies have revealed that TIM2-deficient mice (TIM2(-/-)) are more susceptible to the Th2-mediated immune response in an airway inflammation model. Here, we investigated the phenotypic response of TIM2(-/-) mice to cisplatin-induced kidney toxicity. A...

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Identifiers

PMID: 20702592
DOI: 10.1093/toxsci/kfq240
PMCID: PMC2955214

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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