Article
Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.
Human gene therapy methods - 1 Oct 2014
Gomez-Eerland Raquel, Nuijen Bastiaan, Heemskerk Bianca, van Rooij Nienke, van den Berg Joost H, Beijnen Jos H, Uckert Wolfgang, Kvistborg Pia, Schumacher Ton N, Haanen John B A G, Jorritsma Annelies
Abstract excerpt
Advances in genetic engineering have made it possible to generate human T-cell products that carry desired functionalities, such as the ability to recognize cancer cells. The currently used strategies for the generation of gene-modified T-cell products lead to highly differentiated cells within the infusion product, and on the basis of data obtained in preclinical models, this is likely to impact the efficacy of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.