Article
PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function.
Frontiers in immunology - 1 Jan 2022
Suematsu Masaya, Yagyu Shigeki, Nagao Nobuyoshi, Kubota Susumu, Shimizu Yuto, Tanaka Miyuki, Nakazawa Yozo, Imamura Toshihiko
Abstract excerpt
The quality of chimeric antigen receptor (CAR)-T cell products, namely, memory and exhaustion markers, affects the long-term functionality of CAR-T cells. We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory-rich phenotype that is characterized by the high proportion of CD45RA+/C-C chemokine receptor type 7 (CCR7)+ T-cell fraction. To further investigate the favorable...
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