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Article

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

Cancer immunology, immunotherapy : CII - 1 Apr 2013

Yang Shicheng, Ji Yun, Gattinoni Luca, Zhang Ling, Yu Zhiya, Restifo Nicholas P, Rosenberg Steven A, Morgan Richard A

Abstract excerpt

The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric antigen receptors is a promising approach for the adoptive cell therapy of patients with cancer. We previously developed a simplified method for the clinical-scale generation of central memory-like (Tcm) CD8+ T cells following transduction with lentivirus encoding anti-tumor TCR and culture in the presence of IL-2. In...

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Identifiers

PMID: 23207483
DOI: 10.1007/s00262-012-1378-2
PMCID: PMC6354242

Genes

CCR7
CD27
CD28
LIN28A
NANOG
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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