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Article

Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours.

The Journal of pathology - 1 Nov 2014

Karube Kennosuke, Martínez Daniel, Royo Cristina, Navarro Alba, Pinyol Magda, Cazorla Maite, Castillo Paola, Valera Alexandra, Carrió Anna, Costa Dolors, Colomer Dolors, Rosenwald Andreas, Ott German, Esteban Daniel, Giné Eva, López-Guillermo Armando, Campo Elias

Abstract excerpt

Follicular lymphoma (FL) is one of the most common malignant lymphomas. The t(14;18)(q32;q21) translocation is found in about 80% of cases and plays an important role in lymphomagenesis. However, the molecular mechanisms involved in the development and transformation of this lymphoma are not fully understood. Gain-of-function mutations of NOTCH1 or NOTCH2 have recently been reported in several B cell lymphoid...

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Topics

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Share to DNA Mutational Analysis
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

Share to Receptor, Notch1

Share to Receptor, Notch2

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 25141821
DOI: 10.1002/path.4428

Genes

NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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