Article
Genetics of follicular lymphoma transformation.
Cell reports - 16 Jan 2014
Pasqualucci Laura, Khiabanian Hossein, Fangazio Marco, Vasishtha Mansi, Messina Monica, Holmes Antony B, Ouillette Peter, Trifonov Vladimir, Rossi Davide, Tabbò Fabrizio, Ponzoni Maurilio, Chadburn Amy, Murty Vundavalli V, Bhagat Govind, Gaidano Gianluca, Inghirami Giorgio, Malek Sami N, Rabadan Raul, Dalla-Favera Riccardo
Abstract excerpt
Follicular lymphoma (FL) is an indolent disease, but 30%-40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by diffuse large B cell lymphoma (DLBCL). The pathogenesis of this process remains largely unknown. Using whole-exome sequencing and copy-number analysis, we show here that the dominant clone of FL and transformed FL (tFL) arise by divergent evolution from a...
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