Article
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms.
Leukemia - 1 Oct 2023
Kalmbach Sabrina, Grau Michael, Zapukhlyak Myroslav, Leich Ellen, Jurinovic Vindi, Hoster Eva, Staiger Annette M, Kurz Katrin S, Weigert Oliver, Gaitzsch Erik, Passerini Verena, Engelhard Marianne, Herfarth Klaus, Beiske Klaus, Micci Francesca, Möller Peter, Bernd Heinz-Wolfram, Feller Alfred C, Klapper Wolfram, Stein Harald, Hansmann Martin-Leo, Hartmann Sylvia, Dreyling Martin, Holte Harald, Lenz Georg, Rosenwald Andreas, Ott German, Horn Heike
Abstract excerpt
Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far. Comprehensive analysis with profiling of somatic copy number alterations (SCNA) and whole exome sequencing (WES) was performed in 147 lFL and 122 sFL. Putative targets were analyzed for gene and protein expression....
Topics
- Humans
- Lymphoma, Follicular
- Translocation, Genetic
- Proto-Oncogene Proteins c-bcl-2
- Mutation
- In Situ Hybridization, Fluorescence