Article
Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations.
Blood - 23 Jul 2009
Leich Ellen, Salaverria Itziar, Bea Silvia, Zettl Andreas, Wright George, Moreno Victor, Gascoyne Randy D, Chan Wing-Chung, Braziel Rita M, Rimsza Lisa M, Weisenburger Dennis D, Delabie Jan, Jaffe Elaine S, Lister Andrew, Fitzgibbon Jude, Staudt Louis M, Hartmann Elena M, Mueller-Hermelink Hans-Konrad, Campo Elias, Ott German, Rosenwald Andreas
Abstract excerpt
Follicular lymphoma (FL) is genetically characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation in approximately 90% of cases. In contrast to FL carrying the t(14;18), their t(14;18)-negative counterparts are less well studied about their immunohistochemical, genetic, molecular, and clinical features. Within a previously published series of 184 FLs grades 1 to 3A with available gene...
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