Article
Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma.
Blood - 13 Mar 2014
Bouska Alyssa, McKeithan Timothy W, Deffenbacher Karen E, Lachel Cynthia, Wright George W, Iqbal Javeed, Smith Lynette M, Zhang Weiwei, Kucuk Can, Rinaldi Andrea, Bertoni Francesco, Fitzgibbon Jude, Fu Kai, Weisenburger Dennis D, Greiner Timothy C, Dave Bhavana J, Gascoyne Randy D, Rosenwald Andreas, Ott German, Campo Elias, Rimsza Lisa M, Delabie Jan, Jaffe Elaine S, Braziel Rita M, Connors Joseph M, Staudt Louis M, Chan Wing-Chung
Abstract excerpt
Follicular lymphoma (FL), the second most common type of non-Hodgkin lymphoma in the western world, is characterized by the t(14;18) translocation, which is present in up to 90% of cases. We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to...
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