Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances.

Abstract excerpt

Follicular lymphomas (FL) are morphologically classified into grades 1, 2, 3a and 3b by the World Health Organization. Bcl2, Bcl6 and CD10 are phenotypic markers of FL while the Bcl2 t(14;18) and Bcl6 t(3q27) gene translocations are common genetic changes. However, to date, there has been no integrated analysis based on phenotype, grade and genotype from large numbers of FL cases. We graded 261 cases of FL and...

Topics

• Biomarkers, Tumor
• Chromosomes, Human, Pair 14
• Chromosomes, Human, Pair 18
• DNA-Binding Proteins
• Genetic Markers
• Genotype
• Humans
• In Situ Hybridization, Fluorescence
• Lymphoma, Follicular
• Phenotype
• Proto-Oncogene Proteins c-bcl-2
• Proto-Oncogene Proteins c-bcl-6