Article
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma.
International journal of molecular sciences - 20 Nov 2020
Larrea Erika, Fernandez-Mercado Marta, Guerra-Assunção José Afonso, Wang Jun, Goicoechea Ibai, Gaafar Ayman, Ceberio Izaskun, Lobo Carmen, Okosun Jessica, Enright Anton J, Fitzgibbon Jude, Lawrie Charles H
Abstract excerpt
Follicular lymphoma (FL) is a common indolent B-cell lymphoma that can transform into the more aggressive transformed FL (tFL). However, the molecular process driving this transformation is uncertain. In this work, we aimed to identify microRNA (miRNA)-binding sites recurrently mutated in follicular lymphoma patients, as well as in transformed FL patients. Using whole-genome sequencing data from FL tumors, we...
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