Article
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
ACS chemical biology - 17 Oct 2014
Cho Hyekyung P, Garcia-Barrantes Pedro M, Brogan John T, Hopkins Corey R, Niswender Colleen M, Rodriguez Alice L, Venable Daryl F, Morrison Ryan D, Bubser Michael, Daniels J Scott, Jones Carrie K, Conn P Jeffrey, Lindsley Craig W
Abstract excerpt
Schizophrenia is a complex and highly heterogeneous psychiatric disorder whose precise etiology remains elusive. While genome-wide association studies (GWAS) have identified risk genes, they have failed to determine if rare coding single nucleotide polymorphisms (nsSNPs) contribute in schizophrenia. Recently, two independent studies identified 12 rare, deleterious nsSNPS in the GRM1 gene, which encodes the...
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