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Article

Deleterious GRM1 mutations in schizophrenia.

PloS one - 1 Jan 2012

Ayoub Mohammed Akli, Angelicheva Dora, Vile David, Chandler David, Morar Bharti, Cavanaugh Juleen A, Visscher Peter M, Jablensky Assen, Pfleger Kevin D G, Kalaydjieva Luba

Abstract excerpt

We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose documented role as a modulator of neuronal signalling and synaptic plasticity makes it a plausible schizophrenia...

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Source

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Identifiers

PMID: 22448230
DOI: 10.1371/journal.pone.0032849
PMCID: PMC3308973

Genes

GRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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