Article
A quantitative comparison of single-cell whole genome amplification methods.
PloS one - 1 Jan 2014
de Bourcy Charles F A, De Vlaminck Iwijn, Kanbar Jad N, Wang Jianbin, Gawad Charles, Quake Stephen R
Abstract excerpt
Single-cell sequencing is emerging as an important tool for studies of genomic heterogeneity. Whole genome amplification (WGA) is a key step in single-cell sequencing workflows and a multitude of methods have been introduced. Here, we compare three state-of-the-art methods on both bulk and single-cell samples of E. coli DNA: Multiple Displacement Amplification (MDA), Multiple Annealing and Looping Based...
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