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Article

Comparison of multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC) in single-cell sequencing.

PloS one - 1 Jan 2014

Chen Minfeng, Song Pengfei, Zou Dan, Hu Xuesong, Zhao Shancen, Gao Shengjie, Ling Fei

Abstract excerpt

Single-cell sequencing promotes our understanding of the heterogeneity of cellular populations, including the haplotypes and genomic variability among different generation of cells. Whole-genome amplification is crucial to generate sufficient DNA fragments for single-cell sequencing projects. Using sequencing data from single sperms, we quantitatively compare two prevailing amplification methods that extensively...

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Identifiers

PMID: 25485707
DOI: 10.1371/journal.pone.0114520
PMCID: PMC4259343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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