Article
One bacterial cell, one complete genome.
PloS one - 23 Apr 2010
Woyke Tanja, Tighe Damon, Mavromatis Konstantinos, Clum Alicia, Copeland Alex, Schackwitz Wendy, Lapidus Alla, Wu Dongying, McCutcheon John P, McDonald Bradon R, Moran Nancy A, Bristow James, Cheng Jan-Fang
Abstract excerpt
While the bulk of the finished microbial genomes sequenced to date are derived from cultured bacterial and archaeal representatives, the vast majority of microorganisms elude current culturing attempts, severely limiting the ability to recover complete or even partial genomes from these environmental species. Single cell genomics is a novel culture-independent approach, which enables access to the genetic...
Topics
- Bacteria
- Genes, Bacterial
- Genetic Variation
- Genome, Bacterial
- Genomics
- Metagenomics
- Nucleic Acid Amplification Techniques
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA