Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently.

Gut - 1 May 2015

Beilfuss Anja, Sowa Jan-Peter, Sydor Svenja, Beste Mechthild, Bechmann Lars P, Schlattjan Martin, Syn Wing-Kin, Wedemeyer Inga, Mathé Zoltan, Jochum Christoph, Gerken Guido, Gieseler Robert K, Canbay Ali

Abstract excerpt

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin D (VD). Due to known crosstalk between VD and transforming growth factor (TGF)-β signalling, VD has been proposed as an antifibrotic treatment. DESIGN: We evaluated the association between VD, the vitamin D receptor (VDR) and liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Evaluation, Preclinical
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatic Stellate Cells

Share to Non-alcoholic Fatty Liver Disease

Share to Obesity, Morbid

Share to Receptors, Calcitriol

Share to Smad2 Protein

Share to Vitamin D

Source

Identifiers

PMID: 25134788
DOI: 10.1136/gutjnl-2014-307024

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently.PMID 25134788Read ↗

Vitamin D and nonalcoholic fatty liver diseaseSemantic proximity Read ↗

DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis DevelopmentSemantic proximity Read ↗

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic ResponseSemantic proximity Read ↗

Vitamin D Level and Vitamin D Receptor Genetic Variation Were Involved in the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study.Semantic proximity Read ↗

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.Semantic proximity Read ↗

Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptorSemantic proximity Read ↗

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.Semantic proximity Read ↗

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal MyofibroblastsSemantic proximity Read ↗

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.Semantic proximity Read ↗

The vitamin D receptor Taq I polymorphism is associated with reduced VDR and increased PDIA3 protein levels in human intestinal fibroblasts.Semantic proximity Read ↗

PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.