Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.

doi:10.1002/hep.22697

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.

Hepatology (Baltimore, Md.) - 1 Mar 2009

Guo Jinsheng, Loke Johnny, Zheng Feng, Hong Feng, Yea Steven, Fukata Masayuki, Tarocchi Mirko, Abar Olivia T, Huang Hongjin, Sninsky John J, Friedman Scott L

Abstract excerpt

UNLABELLED: In a recent study, a single nucleotide polymorphism (SNP) of the Toll-like receptor 4 (TLR4) gene (c.1196C>T [rs4986791, p.T399I]) emerged as conferring protection from fibrosis progression compared to a major, wild-type (WT) CC allele (p.T399). The present study examined the function...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatic Stellate Cells

Share to Interleukin-6

Share to Lipopolysaccharides

Share to Liver Cirrhosis

Share to Myeloid Differentiation Factor 88

Share to NF-kappa B

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 19085953
DOI: 10.1002/hep.22697
PMCID: PMC2891538

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19085953-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.PMID 19085953Read ↗

A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation.Semantic proximity Read ↗

Impact of Toll-like Receptors 2(TLR2) and TLR 4 Gene Variations on HCV Susceptibility, Response to Treatment and Development of Hepatocellular Carcinoma in Cirrhotic HCV PatientsSemantic proximity Read ↗

Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.Semantic proximity Read ↗

TLR3 and TLR4 SNP variants in the liver disease resulting from hepatitis B virus and hepatitis C virus infectionSemantic proximity Read ↗

SOCS1 and pattern recognition receptors: TLR9 and RIG-I; novel haplotype associations in Egyptian fibrotic/cirrhotic patients with HCV genotype 4.Semantic proximity Read ↗

TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients.Semantic proximity Read ↗

Cytokine production in patients with cirrhosis and TLR4 polymorphisms.Semantic proximity Read ↗

Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy.Semantic proximity Read ↗

Toll-like receptor polymorphisms compromise the inflammatory response against bacterial antigen translocation in cirrhosis.Semantic proximity Read ↗

Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B-Related Acute Liver Failure.Semantic proximity Read ↗

The circAno6/miR-296-3p/TLR4 signaling axis mediates the inflammatory response to induce the activation of hepatic stellate cellsSemantic proximity Read ↗

TLR4 promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis by a mechanism independent of hepatocytes and inflammatory cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.