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Article

DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development

22 Feb 2023

Abstract excerpt

BACKGROUND: This study investigated the role and potential mechanisms of Discoidin domain receptors-1 (DDR1) during liver fibrogenesis. METHODS: Blood and livers were collected from mice. In the in vitro experiments, human normal hepatocyte (LO2 cell line) and human hepatoma cells (HepG2 cell line) with overexpressed DDR1 (DDR1-OE) or DDR1 knockdown (DDR1-KD) were constructed by transfecting the corresponding...

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PMID: 36809965
DOI: 10.2174/1874467216666230222124515

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