MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor

Abstract excerpt

Significance Hepatic fibrosis is the final common pathological outcome of many chronic liver diseases and occurs when hepatic stellate cells (HSCs) are activated to become fibrogenic myofibroblasts. To date, there are still no approved antifibrotic therapies. Accumulating evidence suggests that targeting the deregulated miRNAs could mitigate disease outcomes. In this study, using a well-studied model of human...

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