Article
A note on the efficiencies of sampling strategies in two-stage Bayesian regional fine mapping of a quantitative trait.
Genetic epidemiology - 1 Nov 2014
Chen Zhijian, Craiu Radu V, Bull Shelley B
Abstract excerpt
In focused studies designed to follow up associations detected in a genome-wide association study (GWAS), investigators can proceed to fine-map a genomic region by targeted sequencing or dense genotyping of all variants in the region, aiming to identify a functional sequence variant. For the analysis of a quantitative trait, we consider a Bayesian approach to fine-mapping study design that incorporates...
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