Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and Correlations

13 Sept 2000

Abstract excerpt

The formation of insoluble protein aggregates is a hallmark of Huntington's disease (HD) and related neurodegenerative disorders, such as dentatorubral pallidoluysian atrophy (DRPLA), spinal bulbar muscular atrophy (SBMA) and the spinocerebellar ataxia (SCA) type 1, 2, 3, 6 and 7. These disorders are caused by an expanded polyglutamine (polyQ) tract in otherwise unrelated proteins. They are characterized by...

Topics

Join the communities discussing this publication.

Genetic Neurodegenerative Diseases
Mitochondrial Function and Pathology
Neurological disorders and treatments

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11076024
DOI: 10.1515/bc.2000.114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and CorrelationsPMID 11076024Read ↗

Polyglutamine Diseases and Transport ProblemsSemantic proximity Read ↗

Protein misfolding inside cells: The case of huntingtin and Huntington's diseaseSemantic proximity Read ↗

A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions.Semantic proximity Read ↗

Monomeric, Oligomeric and Polymeric Proteins in Huntington Disease and Other Diseases of Polyglutamine ExpansionSemantic proximity Read ↗

Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative DiseaseSemantic proximity Read ↗

Polyglutamine aggregation in Huntington and related diseases.Semantic proximity Read ↗

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.Semantic proximity Read ↗

Neurotoxic protein oligomerisation associated with polyglutamine diseases.Semantic proximity Read ↗

Pathogenesis of polyglutamine disorders: aggregation revisitedSemantic proximity Read ↗

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity.Semantic proximity Read ↗

Protein aggregation and neurodegeneration: clues from a yeast model of Huntington's disease.Semantic proximity Read ↗

Huntington's disease: from pathology and genetics to potential therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.