Article
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
PLoS genetics - 1 Jun 2011
Tomlinson Ian P M, Carvajal-Carmona Luis G, Dobbins Sara E, Tenesa Albert, Jones Angela M, Howarth Kimberley, Palles Claire, Broderick Peter, Jaeger Emma E M, Farrington Susan, Lewis Annabelle, Prendergast James G D, Pittman Alan M, Theodoratou Evropi, Olver Bianca, Walker Marion, Penegar Steven, Barclay Ella, Whiffin Nicola, Martin Lynn, Ballereau Stephane, Lloyd Amy, Gorman Maggie, Lubbe Steven, Howie Bryan, Marchini Jonathan, Ruiz-Ponte Clara, Fernandez-Rozadilla Ceres, Castells Antoni, Carracedo Angel, Castellvi-Bel Sergi, Duggan David, Conti David, Cazier Jean-Baptiste, Campbell Harry, Sieber Oliver, Lipton Lara, Gibbs Peter, Martin Nicholas G, Montgomery Grant W, Young Joanne, Baird Paul N, Gallinger Steven, Newcomb Polly, Hopper John, Jenkins Mark A, Aaltonen Lauri A, Kerr David J, Cheadle Jeremy, Pharoah Paul, Casey Graham, Houlston Richard S, Dunlop Malcolm G
Abstract excerpt
Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several of these tagSNPs are near bone morphogenetic protein (BMP) pathway loci. The penalty of multiple testing implicit in GWAS increases the attraction of complementary approaches for disease gene discovery, including candidate gene- or...
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