Article
Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating CD9 and PLEKHG6.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2020
Ke Juntao, Tian Jianbo, Mei Shufang, Ying Pingting, Yang Nan, Wang Xiaoyang, Zou Danyi, Peng Xiating, Yang Yang, Zhu Ying, Gong Yajie, Wang Zhihua, Gong Jing, Zhong Rong, Chang Jiang, Miao Xiaoping
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified dozens of loci associated with colon and rectal adenocarcinoma risk. As tissue-specific super-enhancers (SE) play important roles in tumorigenesis, we systematically investigate SEs and inner variants in established GWAS loci to decipher the underlying biological mechanisms. METHODS: Through a comprehensive bioinformatics analysis on multi-omics...
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