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Article

GREM1 signaling in cancer: tumor promotor and suppressor?

24 Aug 2023

Abstract excerpt

GREMLIN1 (GREM1) is member of a family of structurally and functionally related secreted cysteine knot proteins, which act to sequester and inhibit the action of multifunctional bone morphogenetic proteins (BMPs). GREM1 binds directly to BMP dimers, thereby preventing BMP-mediated activation of BMP type I and type II receptors. Multiple reports identify the overexpression of GREM1 as a contributing factor in a...

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PMID: 37615860
DOI: 10.1007/s12079-023-00777-4

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