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Article

The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling.

Cancer medicine - 1 Dec 2014

Sankin Alexander, Hakimi Abraham A, Mikkilineni Nina, Ostrovnaya Irina, Silk Mikhail T, Liang Yupu, Mano Roy, Chevinsky Michael, Motzer Robert J, Solomon Stephen B, Cheng Emily H, Durack Jeremy C, Coleman Jonathan A, Russo Paul, Hsieh James J

Abstract excerpt

Primary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity may lead to an underestimation of the mutational burden detected from a single site evaluation. We sought to characterize the extent of clonal branching involving key tumor suppressor mutations in primary ccRCC and determine if genetic heterogeneity could limit the mutation profiling from a single region assessment. Ex vivo core needle biopsies...

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Share to Biomarkers, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to PBRM1 gene

Share to Genes, Tumor Suppressor

Share to Genetic Heterogeneity

Share to Genetic Predisposition to Disease

Share to Kidney Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25124064
DOI: 10.1002/cam4.293
PMCID: PMC4298374

Genes

BAP1
PBRM1
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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