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Detecting truly clonal alterations from multi-region profiling of tumours

27 Mar 2017

Abstract excerpt

Modern cancer therapies aim at targeting tumour-specific alterations, such as mutations or neo-antigens, and maximal treatment efficacy requires that targeted alterations are present in all tumour cells. Currently, treatment decisions are based on one or a few samples per tumour, creating uncertainty on whether alterations found in those samples are actually present in all tumour cells. The probability of...

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PMID: 28344344
DOI: 10.1038/srep44991

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