Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.

doi:10.1002/ijc.29140

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.

International journal of cancer - 1 Apr 2015

Gargalionis Antonios N, Korkolopoulou Penelope, Farmaki Elena, Piperi Christina, Dalagiorgou Georgia, Adamopoulos Christos, Levidou Georgia, Saetta Angelica, Fragkou Paraskevi, Tsioli Panagiota, Kiaris Hippokratis, Zizi-Serbetzoglou Adamantia, Karavokyros Ioannis, Papavassiliou Kostas A, Tsavaris Nikolaos, Patsouris Efstratios, Basdra Efthimia K, Papavassiliou Athanasios G

Abstract excerpt

The polycystins PC1 and PC2 are emerging as major players in mechanotransduction, a process that influences all steps of the invasion/metastasis cascade. We hypothesized that PC1 and PC2 facilitate cancer aggressiveness. Immunoblotting, RT-PCR, semi-quantitative and quantitative real-time PCR and FACS analyses were employed to investigate the effect of polycystin overexpression in colorectal cancer (CRC) cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Lymphatic Metastasis

Share to Microsatellite Instability

Share to Neoplasm Grading

Share to TOR Serine-Threonine Kinases

Share to TRPP Cation Channels

Share to Tumor Burden

Source

Open in PubMed

Identifiers

PMID: 25123959
DOI: 10.1002/ijc.29140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.PMID 25123959Read ↗

The role of Popeye domain-containing protein 1 (POPDC1) in the progression of the malignant phenotype.Semantic proximity Read ↗

Comprehensive characterization of PKHD1 mutation in human colon cancer.Semantic proximity Read ↗

Polycystin-1: function as a mechanosensor.Semantic proximity Read ↗

PTOV1 Exerts Pro-oncogenic Role in Colorectal Cancer by Modulating SQSTM1-Mediated Autophagic Degradation of p53Semantic proximity Read ↗

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complexSemantic proximity Read ↗

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.Semantic proximity Read ↗

Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway.Semantic proximity Read ↗

AHNAK2: a potential diagnostic biomarker for pancreatic cancer related to cellular motilitySemantic proximity Read ↗

Role of the polycystins as mechanosensors of extracellular stiffness.Semantic proximity Read ↗

Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuliSemantic proximity Read ↗

Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancerSemantic proximity Read ↗

Stable Knockdown of Polycystin-1 Confers Integrin-α2β1–Mediated Anoikis ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.