Article
The role of Popeye domain-containing protein 1 (POPDC1) in the progression of the malignant phenotype.
British journal of pharmacology - 1 Jun 2022
Tucker Steven J, Zorn Alina J
Abstract excerpt
The Popeye domain-containing protein 1 (POPDC1), a tight junction-associated transmembrane protein with a unique binding site for cAMP, has been shown to act as a tumour suppressor in cancer cells. Through interaction with many downstream effectors and signalling pathways, POPDC1 promotes cell adhesion and inhibits uncontrolled cell proliferation, epithelial-to-mesenchymal transition and metastasis. However,...
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