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Article

Comprehensive characterization of PKHD1 mutation in human colon cancer.

Cancer medicine - 1 Jan 2024

Han Lu, Gong Fangming, Wu Xuxiaochen, Tang Wanxiangfu, Bao Hua, Wang Yue, Wang Daizhenru, Sun Yulan, Li Peng

Abstract excerpt

INTRODUCTION: The PKHD1 (Polycystic Kidney and Hepatic Disease 1) gene is essential for producing fibrocystin or polyductin, which is crucial in various cellular functions. Mutations in PKHD1 have been found to be involved in the development and progression of colorectal cancer (CRC). Along with APC, TP53, and KRAS, PKHD1 is one of the most frequently mutated genes in CRC. PKHD1 expression is governed by the...

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PMID: 38178618
DOI: 10.1002/cam4.6796
PMCID: PMC10807659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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