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Article

Stable Knockdown of Polycystin-1 Confers Integrin-α2β1–Mediated Anoikis Resistance

27 Sept 2006

Abstract excerpt

The mechanisms of action of polycystin-1 (PC1) have been difficult to dissect because of its interaction with multiple factors, the heterogeneity of the genetic mutations, and the complexity of the experimental animal models. Here, stable knockdown of PC1 in MDCK epithelial cells was achieved by lentiviral-mediated delivery of a specific small interfering RNA for PKD1. The reduction of PC1 expression prevented...

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PMID: 17005934
DOI: 10.1681/asn.2006030234

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