Article
Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.
ACS chemical neuroscience - 15 Oct 2014
Zanotti-Fregonara Paolo, Zhang Yi, Jenko Kimberly J, Gladding Robert L, Zoghbi Sami S, Fujita Masahiro, Sbardella Gianluca, Castellano Sabrina, Taliani Sabrina, Martini Claudia, Innis Robert B, Da Settimo Federico, Pike Victor W
Abstract excerpt
The imaging of translocator 18 kDa protein (TSPO) in living human brain with radioligands by positron emission tomography (PET) has become an important means for the study of neuroinflammatory conditions occurring in several neuropsychiatric disorders. The widely used prototypical PET radioligand [(11)C](R)-PK 11195 ([(11)C](R)-1;...
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