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Article

Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.

Journal of virology - 1 Oct 2014

Sheldon Julie, Beach Nathan M, Moreno Elena, Gallego Isabel, Piñeiro David, Martínez-Salas Encarnación, Gregori Josep, Quer Josep, Esteban Juan Ignacio, Rice Charles M, Domingo Esteban, Perales Celia

Abstract excerpt

Passage of hepatitis C virus (HCV) in human hepatoma cells resulted in populations that displayed partial resistance to alpha interferon (IFN-α), telaprevir, daclatasvir, cyclosporine, and ribavirin, despite no prior exposure to these drugs. Mutant spectrum analyses and kinetics of virus production in the absence and presence of drugs indicate that resistance is not due to the presence of drug resistance...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Drug Resistance, Viral

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Share to Real-Time Polymerase Chain Reaction

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Source

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Identifiers

PMID: 25122776
DOI: 10.1128/JVI.01860-14
PMCID: PMC4178724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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