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Article

Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance.

Journal of virology - 1 Sept 1996

Novella I S, Cilnis M, Elena S F, Kohn J, Moya A, Domingo E, Holland J J

Abstract excerpt

Vesicular stomatitis virus (VSV) populations were repeatedly passaged in L-929 cells treated with alpha interferon (IFN-alpha) at levels of 25 U/ml. This IFN-alpha concentration induced a 99.9% inhibition of viral yield in standard infections. Analysis of viral fitness (overall replicative abilit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8709273
DOI: 10.1128/JVI.70.9.6414-6417.1996
PMCID: PMC190671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8709273-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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