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Article

The competing roles of virus replication and hepatocyte death rates in the emergence of drug-resistant mutants: theoretical considerations.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2005

Litwin Samuel, Toll Eugene, Jilbert Allison R, Mason William S

Abstract excerpt

Lamivudine therapy of individuals chronically infected with hepatitis B virus (HBV) may eventually fail due to the emergence of drug-resistant mutants. Nonetheless, the durability of the response generally exceeds 6-12 months. This durability appeared surprising in view of published evidence that the replication rate of drug-resistant mutants might be at least 10% of the replication rate of uninhibited wild-type...

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Identifiers

PMID: 16461233
DOI: 10.1016/s1386-6532(05)80018-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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