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Article

Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype.

Journal of virology - 1 Jul 2013

Perales Celia, Beach Nathan M, Gallego Isabel, Soria Maria Eugenia, Quer Josep, Esteban Juan Ignacio, Rice Charles, Domingo Esteban, Sheldon Julie

Abstract excerpt

Cell culture-produced hepatitis C virus (HCV) has been subjected to up to 100 serial passages in human hepatoma cells in the absence or presence of different doses of alpha interferon (IFN-α). Virus survival, genetic changes, fitness levels, and phenotypic traits have been examined. While high in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23637397
DOI: 10.1128/JVI.02824-12
PMCID: PMC3700284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23637397-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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